SBIO Performance — ALPS Medical Breakthroughs ETF
Data updated: 2026-07-29
SBIO returned +6.35% year to date and +87.48% over one year to May 2026. Annualised returns are +21.29% over 3 years and +3.84% over 5 years. The fund beat its Health Care Equity category average: $100 invested three years ago grew to $178, against $131 for the category, and to $187 over one year, against $129. Volatility over the past three years was 26.53% a year. In the 12 months to May 2026 the fund took in a net $23.5M, and assets reached $161.79M.
SBIO Growth of $100
What $100 invested in ALPS Medical Breakthroughs ETF grew to, compounded from monthly returns reported on SEC Form N-PORT, against the Health Care Equity category average over the same months.
| Period | SBIO | Category average |
|---|---|---|
| 1 year (Jun 2025 – May 2026) | $187 | $129 |
| 3 years (Jun 2023 – May 2026) | $178 | $131 |
| 5 years (Jun 2021 – May 2026) | $121 | $116 |
| Since data start (Sep 2019 – May 2026) | $164 | $173 |
SBIO Trailing Returns
Total returns to May 2026, from SEC N-PORT.
| Period | Total return |
|---|---|
| YTD | +6.35% |
| 1 year | +87.48% |
| 3 years (annualised) | +21.29% |
| 5 years (annualised) | +3.84% |
SBIO Annual Returns
Calendar-year total returns of ALPS Medical Breakthroughs ETF, compounded from monthly SEC N-PORT returns. Partial years show the months covered.
| Year | Total return |
|---|---|
| 2026 (Jan–May) | +6.35% |
| 2025 | +54.21% |
| 2024 | +4.17% |
| 2023 | +8.16% |
| 2022 | −27.86% |
| 2021 | −17.53% |
| 2020 | +21.21% |
| 2019 (Sep–Dec) | +22.80% |
SBIO Monthly Returns
Monthly total returns as reported on SEC Form N-PORT.
| Year | Jan | Feb | Mar | Apr | May | Jun | Jul | Aug | Sep | Oct | Nov | Dec |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 2026 | +0.3% | +0.6% | +1.3% | +2.6% | +1.4% | — | — | — | — | — | — | — |
| 2025 | −0.5% | −4.9% | −9.1% | +4.0% | −2.2% | +3.7% | +8.7% | +6.5% | +11.5% | +16.1% | +10.5% | +2.6% |
| 2024 | +0.6% | +11.4% | −2.9% | −8.5% | +1.6% | +0.8% | +11.4% | 0.0% | +0.4% | +0.4% | +3.0% | −11.6% |
| 2023 | +6.7% | −7.0% | −10.0% | +9.9% | +5.4% | 0.0% | +1.5% | −7.2% | −8.3% | −10.1% | +7.5% | +25.1% |
| 2022 | −17.5% | −3.6% | +0.3% | −15.4% | −9.8% | +7.7% | +7.6% | +6.3% | −5.0% | +2.0% | +1.9% | −2.6% |
| 2021 | +9.3% | −1.4% | −9.1% | −0.2% | −6.9% | +5.0% | −9.9% | +6.4% | −2.9% | +1.1% | −6.8% | −1.6% |
| 2020 | −6.0% | −2.9% | −17.5% | +19.7% | +8.7% | +0.8% | −4.4% | +3.5% | −0.6% | +6.1% | +12.3% | +4.6% |
| 2019 | — | — | — | — | — | — | — | — | −8.3% | +10.3% | +13.4% | +7.1% |
SBIO Risk
Risk measures from monthly returns over Jun 2023 – May 2026.
- 3-year volatility (annualised): 26.53%
- 3-year Sharpe ratio: 0.63 (vs 4.5% risk-free rate)
- Best month: +25.11% (Dec 2023)
- Worst month: −11.64% (Dec 2024)
SBIO Fund Flows
Monthly money in and out of ALPS Medical Breakthroughs ETF, from SEC Form N-PORT.
- 12-month net flow: $23.5M
- 12-month gross sales (incl. reinvestments): $79.7M
- Sales ÷ redemptions: 1.42×
| Month | Sales | Redemptions | Net flow |
|---|---|---|---|
| May 2026 | $4.1M | $0 | $4.1M |
| Apr 2026 | $22.2M | $1.4M | $20.7M |
| Mar 2026 | $0 | $7.4M | −$7.4M |
| Feb 2026 | $3.8M | $5.1M | −$1.3M |
| Jan 2026 | $11.8M | $1.2M | $10.5M |
| Dec 2025 | $20.2M | $0 | $20.2M |
| Nov 2025 | $10.6M | $0 | $10.6M |
| Oct 2025 | $4.2M | $25.3M | −$21.1M |
| Sep 2025 | $2.7M | $955K | $1.8M |
| Aug 2025 | $0 | $876K | −$876K |
| Jul 2025 | $0 | $9.2M | −$9.2M |
| Jun 2025 | $0 | $4.7M | −$4.7M |
SBIO Assets Under Management
Net assets of ALPS Medical Breakthroughs ETF by report date, from SEC N-PORT filings.
| Report date | Net assets |
|---|---|
| 2026-05-31 | $161.79M |
| 2026-02-28 | $138.03M |
| 2025-11-30 | $104.61M |
| 2025-08-31 | $80.98M |
| 2025-05-31 | $81.20M |
| 2025-02-28 | $94.09M |
| 2024-11-30 | $123.20M |
| 2024-08-31 | $114.12M |
| 2024-05-31 | $103.33M |
| 2024-02-29 | $119.01M |
| 2023-11-30 | $83.69M |
| 2023-08-31 | $101.07M |
For information only. Not investment advice: figures are as reported in SEC filings and may contain errors or be out of date. Past performance does not guarantee future results.